GSK583 is a selective inhibitor of RIP2 Kinase and IC50 value is 5 nM.

Nec-34 can synergize with Nec-1s to inhibit RIPK1 in vitro and in vivo.

RIPA-56 is a RIP1 inhibitor with EC50 value of 28nM. It efficiently reduced TNFα-induced mortality and multi-organ damage.

GSK2983559 free acid is a small-molecule inhibitor of RIP2 kinase. GSK2983559 free acid potently binds to RIP2 kinase with good kinase specificity and has excellent activity in blocking many proinflammatory cytokine responses in vivo .

HS1371 is an ATP-competitive and novel kinase inhibitor of RIP3-mediated necroptosis which can directly bind to RIP3.

GSK'547 is a highly selective and potent RIP1 inhibitor with improved oral bioavailability.

GSK3145095 is a potent and orally active RIPK1 inhibitor with IC50 of 5 nM and potential antineoplastic and immunomodulatory activities.

GSK'963 inhibits RIP1-dependent cell death with an IC50 of between 1 and 4 nM in human and murine cells.

Necrostatin-1 is an inhibitor of RIP1 and can decrease TNF-α-induced necroptosis with EC50 of 490 nM.

GSK'481 can inhibit RIP1 WT S166 phosphorylation in human vs mouse plasmids overexpressed in HEK293T cells.

GSK2982772 is an inhibitor of receptor interacting protein 1 (RIP1) with IC50 of 16 nM and it is used for the treatment of inflammatory diseases.